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Observed Purposes & Effects of DSIP Peptide

Sleep regulation

DSIP offers some sleep-inducing effect thanks to its ability to influence the production of certain neurotransmitters within the body. These substances particularly help to slow-wave sleep which is essential in promoting healthy sleep patterns.

Prevents neurodegeneration

This neuropeptide contains some neuroprotective properties that help it protect your nervous system from oxidative stress. As a result, it has become a practical aid in the treatment and management of neurodegenerative conditions like Parkison’s disease and Alzheimer’s. 

Therapeutic agent

DSIP has been widely touted as a potential therapy option for diseases like Insomnia, neurodegenerative disorders, and chronic pain conditions like fibromyalgia. Several clinical studies have shown its promising benefits against conditions that affect the nervous system.

Off-label Uses

The DSIP peptide therapy is yet to be FDA-approved. This means that you don’t require any prescription for use and can be obtained over-the-counter. However, it’s an affordable and more potent option for the treatment of sleep disorders compared to drugs like Mirtazapine or Trazodone.

DSIP’s Quantity and Forms

Quantity

DSIP doses are typically available in doses of between 100mg to 300mg. A higher dosage indicates higher peptide efficacy and usage may vary depending on individual response and needs. 

Dosing frequency can also vary. It can be administered once daily or weekly depending on patient’s reaction to the medication. Ideal dosage time is at night at least three hours before you go to bed. Make sure to follow dosage instructions to avoid adverse side effects.

Forms

The DSIP formulation typically constitutes lyophilized protein with no additives. This comes in powder form. 

However, to enhance longevity and reconstitute the peptide, its dissolved in bacteriostatic water with 0.9% benzyl alcohol. For this reason, DSIP is administered in injectable form typically beneath fatty layers of the skin.

Be aware that in this form, DSIP should be stored between 2 to 80 C. It can last up to four weeks in this form. 

Instruction

• All vial tops should be thoroughly disinfected using alcohol swabs before administering dosage.
• Avoid freeze-thawing cycles when storing DSIP to maintain stability.      
• Don’t expose to direct heat or light when reconstituting DSIP. Remember to always keep the bacteriostatic water and peptide at room temperature.
• Sonication is the recommended method for DSIP dissolution. Be aware that vigorous shaking can affect product integrity.
• Your DSIP solution should be clear before use.

Ingredients

• A single non-glycosylated polypeptide chain containing 15 amino acids.

How Does DSIP Work?

DSIP is an endogenous neuropeptide that influences sleep cycles thanks to its modulatory effects within the central nervous system. And, because of its unique biochemical properties, this peptide can withstand enzyme degradation improving its potency.

Its ability to remain relatively stable at room temperature is also an added advantage. However, due to limited research, it difficult to fully tell the scope of DSIP mechanism in action.

Observed Potential Benefits of DSIP in Research

Several studies have shown encouraging effects of this neuropeptide. Here are some potential benefits of DSIP use. 

Promotes healthy sleep patterns

Your sleep cycle can be grouped into wake, rem and deep sleep categories. Unlike other sleep-promoting substances and sedatives, DSIP doesn’t alter the duration of your sleep stages. It’s a key supporter of your circadian rhythm hence it’ role in influencing your sleep cycle.

Instead, it enhances your ability to find and achieve restful sleep. It does this by cutting down the amount of time it takes for you to fall asleep and improving deep sleep phases. This is especially important for patients dealing with insomnia. 

Hormone regulation

As mentioned earlier, DSIP is a neuropeptide. This means that it plays an active role in neuroendocrine regulation and the production of anterior pituitary hormones. 

In humans, DSIP particularly influences the production of the growth hormone (GH), luteinizing hormone (LH), and adrenocorticotropic hormone (ACTH). By doing this, it simultaneously regulates the release of other hormones that can affect bodily function like somatostatin and cortisol. 

Aids in chronic pain management

DSIP works by altering your perception of pain due to its influence on the nervous system. It does this by triggering the production of endogenous opioids and regulating your circadian rhythm which promotes restorative sleep.

Reduces oxidative stress

Several research studies have shown that this polypeptide an help to improve the ability of mitochondria to release more energy. It does this while minimizing the number of free radicals generated which can increase oxidative stress. This gives DSIP its antioxidant properties.

Regulates blood pressure

Your blood pressure is highly dependent on your circadian cycle. By helping to regulate it, DSIP helps to lower blood pressure and improve overall health. Be aware that this peptide also works to minimize stress which helps enhance its overall effect on your body.

Who Should Consider Using DSIP?

People suffering from insomnia

Individuals suffering from sleep disorders can use DSIP to help regulate and promote healthier sleeping patterns. Research has shown potential for this peptide therapy to help patients achieve more restful and deeper sleep cycles.

Persons suffering from withdrawal symptoms

Patients presenting systems of opioid withdrawal can use DSIP to help manage symptoms like anxiety and erratic behavior. This is because the peptide works to inhibit opioid receptors due to its agonistic activity providing individuals with a sense of calmness and induced slow-wave sleep.

People living with chronic pain and depression

DSIP can also be clinically indicated for patients dealing with these conditions. It’s especially helpful because of its ability to influence the body’s circadian rhythm and cortisol levels. As a result, it helps lower stress levels, alleviate chronic pain, and manage neurodegeneration.

Potential Effects of DSIP

Short-term effects

This peptide therapy is considered relatively safe as long as it’s used correctly. However, common side effects include:

• Headache
• Grogginess
• Dizziness
• Moody behavior and anxiety
• Vertigo
• Low blood pressure
• Nausea
• Reddening at the injection site or allergy reactions.

Long-term effects

The long-term effects of DSIP use are yet to be fully realized due to limited research. Some potential long-term effects may include:

• Hormonal imbalance
• Drowsiness and feeling of constant sedation
• Physiological effects triggered by the endocrine glands

When Will the Results of DSIP Become Noticeable?

Based on available research, you can start to notice changes after at least two weeks of use. Patients may begin to experience better sleep patterns, reduced anxiety, reduced pain, and overall better health.

Dosage Guidelines

Starting dose

The starting dose for DSIP is typically 100mcg. And, it should be administered at least three hours before bedtime. Be aware that dosage titration can be increased or reduced depending on individual response and tolerance.

Frequency

DSIP is administered once daily. The timing however depends on the patient’s needs. Individuals using DSIP to manage chronic pain or stress can use it during the day while those suffering from sleep disorders should preferably take it at night to maximize results.

Duration of use

This varies depending on the patient’s needs and response to medication. The timeline can fall anywhere between two to six weeks. 

DSIP Safety Concerns and Precautions

Dosage and administration

Users should stick to recommended dosing guidelines from researchers and health practitioners. Remember, low dosage is preferred to assess tolerance and avoid potential adverse side effects.
Usually that’s around ~100-250mcg per day before sleep.

Monitoring and reporting

Persons using DSIP should closely monitor their symptoms and progression. In case of any concern or severe side effects, you should consult a doctor immediately.

Granted, DSIP has shown great potential for use as a peptide therapy for many ailments. However, safety considerations and potential side effects must be taken into account. This is paramount for user safety.

FAQs

Is DSIP classified as a hormone?

No. It’s a naturally occurring peptide that’s primarily produced in the hypothalamus, pituitary glands, and the limbic system. It however does provide some physiological effect similar to that of a hormone. 

Is DSIP FDA-approved?

No. At the moment, DSIP is only recognized as a research peptide and primarily used scientific studies. 

Can you combine DSIP with other sleeping aids to help improve outcome?

Yes. Your healthcare provider can recommend combining DSIP peptide therapy with other treatments like melatonin, sedatives, or Cognitive Behavioral Therapy (CBT) for a better and more desired outcome. Be aware that you must consult a medical expert before doing this because some drug interactions can cause severe side effects.

What makes DSIP unique compared to other peptides used to manage sleep disorders?

DSIP is directly absorbed in your gut and can’t be destroyed by enzyme reactions within your body improving its potency and efficacy for treatment.

References

Pollard BJ, Pomfrett CJD. Delta sleep-inducing peptide. Eur J Anaesthesiol. 2001;18(7):419-422. https://doi.org/10.1046/j.1365-2346.2001.00917.x

Steiger A, Holsboer F. Neuropeptides and human sleep. Sleep. 1997;20(11):1038-1052. https://doi.org/10.1093/sleep/20.11.1038

Steiger A. Peptides and Sleep. Published online January 1, 2006.  https://doi.org/10.1016/b978-0-12-385095-9.00255-4

Iyer KS, McCann SM. Delta Sleep-Inducing Peptide (DSIP) stimulates Growth Hormone (GH) release in the rat by hypothalamic and pituitary actions. 1987;8(1):45-48. https://doi.org/10.1016/0196-9781(87)90163-x

Graf M, Kastin AJ. Delta-sleep-inducing peptide (DSIP): An update. 1986;7(6):1165-1187. https://doi.org/10.1016/0196-9781(86)90148-8